Edinson Cavani, David Luiz and Thiago Motta will all miss Paris Saint-Germain's French Cup semi-final against St Etienne on Wednesday, according to coach Laurent Blanc.
Blanc said that despite Cavani having been taken off during Sunday's 3-1 league victory over Marseille with a fatigued thigh, "he won't be fit for tomorrow".
"I should have taken him off at half-time," Blanc lamented, saying he had come to an agreement with the Uruguyan striker that he could play 15-20 minutes of the second-half.
The absence of David Luiz and Thiago Motta had been predicted, both having come off injured in the Marseille match with thigh injuries.
Brazilian Luiz will out for a month and the Brazil-born Italian two weeks, Blanc said, adding that the latter's participation in the Champions League quarter-final against Barcelona on April 15 would be touch and go.
St Etienne welcome back two top players from suspension in Jeremy Clement and Max-Alain Gradel for the PSG match, while Romain Hamouma and Florentin Pogba have been back in training.